FellowPhD Andrea Babelova
Project NameFunctional consequences of renal cell activation due to iron oxide and gold nanoparticle uptake
Host organisationBiomedical Research Center
Duration of the project01.08.2015 - 31.07.2018

Abstract
Despite the fact that more than 40 products, so called „nanomedicines” have already been approved for treatment and diagnosis of various diseases, including cancer, with many others in clinical development (phase I and II clinical trials), very limited body of literature links nanoparticles and kidney function, yet. Kidney is a unique organ characteristic by the high degree of heterogenity. Each cell type in the kidney has a distinct gene expression pattern and changes in the cellular composition largely impact on gene expression that is closely linked to the cell function. Different types of kidney cells have varying sensitivities to toxic substances that may accumulate in kidneys, including nanoparticles. Prolonged residency of nanoparticles in the kidney has been shown to induce toxicity with hallmarks similar to glomerulonephritis affecting all types of renal glomerular cells as mesangial cells, fibroblasts, or podocytes what may form a basis for reduced glomerular filtration capacity in nephrotic kidneys. The main objective of the project is to investigate the interactions of nanomaterials (gold and iron oxide nanoparticles) with the contractile mesangial cells which provide support of the whole glomerular structure and postmitotic podocytes, the principal part of renal filter and uncover potential toxic effects of nanoparticles affecting renal function and so the whole body homeostasis. Considering expansion of nanoparticles into biomedicine the renal toxicity studies are required to avoid potential health risks.

Project Summary with Interim Results